IMB Guest Seminar: The ectopic expression of VE-cadherin in Kupffer cells is controlled by a lineage-specific alternative promoter—potential implications for Kupffer cell function by Lars Muhl, Karolinska Institute
- When
- Friday, 11 September 2026 at 09:15
- Where
- MH Auditorium 1, Hansine Hansens veg 18, 9019 Tromsø
- Price
- See listing
Summary The advent of single-cell RNA-sequencing techniques has marked a significant turning point in our understanding of non-parenchymal cell types across many organs. It has, for example, revealed a molecular heterogeneity of endothelial cell and macrophage populations in the liver, reflecting cellular function and anatomic localization. I will present our recent work illustrating the useability of single-cell transcriptomic analysis combined with epigenetic data to identify regulatory mechanisms of cell type-specific gene expression. I will further present our recent observation that among macrophages, Kupffer cells specifically express VE-cadherin and discuss its potential relevance for Kupffer cell function. Lars Muhl, Dr. rer. nat. is a Senior Researcher in Vascular Biology at the Christer Betsholtz Group at the Department of Medicine, Karolinska Institute, Sweden.
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